Bisphosphonate, 구강악안면외과 영역의 새로운 위험 요소인가?
bisphosphonate, is it an emerging risk factor in oral surgery?
권용대, 윤병욱, Christian Walter,
소속 상세정보
권용대 ( Kwon Yong-Dae ) - 경희대학교 치과대학 구강악안면외과
윤병욱 ( Yoon Byung-Wook ) - 경희대학교 치과대학 구강악안면외과
( Christian Walter ) - 독일 Mainz 대학 구강악안면외과
KMID : 0360120070290050456
Abstract
Since the first description of bisphosphonate related osteonecrosis of the jaw (BRONJ) in 2002, the number of report on the disease has rapidly been increasing. Now, BRONJ is considered as a new entity, which is emerging problem in oral and maxillofacial surgery. Bisphosphonates (BPs) can be categorized into 2 groups: nitrogen-containing and non-nitrogen containing, and nitrogen-containing BPs are considered to have more efficacy and toxicity possibly. It is unusual for osteonecrosis to occur in the maxilla but BRONJ is found in both the mandible and the maxilla, which is one of the special features of BRONJ compared with common infectious osteomyelitis of the jaws. Intravenous BPs are usually more likely to cause BRONJ than oral BPs which are frequently prescribed for osteoporosis and osteopenia. Nonetheless, the use of intravenous BPs cannot be prevented because of systemic condition of the patients. Although it is rare that oral BPs cause BRONJ in osteoporosis/osteopenia patients, we should be aware of BRONJ since the population of the patients is exceedingly increasing with the prolonging of life expectancy. So, we’d like to enlighten upon the problems and solutions of BRONJ.
키워드
Bisphosphonate;Osteonecrosis
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